Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

The low-molecular-weight compound JRC-II-191 inhibits infection of HIV-1 by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor and is therefore an important lead in the development of a potent viral entry inhibitor. Reported here is the use of two orthogonal screening...

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Main Authors: LaLonde, Judith M., Elban, Mark A., Courter, Joel R., Sugawara, Akihiro, Soeta, Takahiro, Madani, Navid, Princiotto, Amy M., Kwon, Young Do, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Sodroski, Joseph, Smith, Amos B.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049263/
https://ncbi.nlm.nih.gov/pubmed/21169023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.11.049
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