Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-ray and Thermodynamic Characterization

[Image: see text] The design, synthesis, thermodynamic and crystallographic characterization of a potent, broad spectrum, second-generation HIV-1 entry inhibitor that engages conserved carbonyl hydrogen bonds within gp120 has been achieved. The optimized antagonist exhibits a submicromolar binding a...

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Autori principali: LaLonde, Judith M., Le-Khac, Matthew, Jones, David M., Courter, Joel R., Park, Jongwoo, Schön, Arne, Princiotto, Amy M., Wu, Xueling, Mascola, John R., Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A., Smith, Amos B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647702/
https://ncbi.nlm.nih.gov/pubmed/23667716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300407y
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