Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-ray and Thermodynamic Characterization

[Image: see text] The design, synthesis, thermodynamic and crystallographic characterization of a potent, broad spectrum, second-generation HIV-1 entry inhibitor that engages conserved carbonyl hydrogen bonds within gp120 has been achieved. The optimized antagonist exhibits a submicromolar binding a...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: LaLonde, Judith M., Le-Khac, Matthew, Jones, David M., Courter, Joel R., Park, Jongwoo, Schön, Arne, Princiotto, Amy M., Wu, Xueling, Mascola, John R., Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A., Smith, Amos B.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647702/
https://ncbi.nlm.nih.gov/pubmed/23667716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300407y
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars