Structure-Based Design, Synthesis and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Cellular infection by HIV-1 is initiated with a binding event between the viral envelope glycoprotein gp120 and the cellular receptor protein CD4. The CD4:gp120 interface is dominated by two hotspots: a hydrophobic gp120 cavity capped by Phe43(CD4) and an electrostatic interaction between residues A...

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Hauptverfasser: LaLonde, Judith M., Kwon, Young Do, Jones, David M., Sun, Alexander W., Courter, Joel R., Soeta, Takahiro, Kobayashi, Toyoharu, Princiotto, Amy M., Wu, Xueling, Schön, Arne, Freire, Ernesto, Kwong, Peter D., Mascola, John R., Sodroski, Joseph, Madani, Navid, Smith, Amos B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376652/
https://ncbi.nlm.nih.gov/pubmed/22497421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300265j
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