O-Alkylhydroxylamines as Rationally-designed Mechanism-based Inhibitors of Indoleamine 2,3-Dioxygenase-1

Indoleamine 2,3-dioxygenase-1 (IDO1) is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression. Recently important advances have been made in understanding IDO1’s catalytic mechanism. Although much rem...

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Publicado en:Eur J Med Chem
Autores principales: Malachowski, William P., Winters, Maria, DuHadaway, James B., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Rahman, Maisha, Sheikh, Eesha, LaLonde, Judith M., Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724314/
https://ncbi.nlm.nih.gov/pubmed/26717206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.028
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