O-Alkylhydroxylamines as Rationally-designed Mechanism-based Inhibitors of Indoleamine 2,3-Dioxygenase-1

Indoleamine 2,3-dioxygenase-1 (IDO1) is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression. Recently important advances have been made in understanding IDO1’s catalytic mechanism. Although much rem...

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Detaylı Bibliyografya
Yayımlandı:Eur J Med Chem
Asıl Yazarlar: Malachowski, William P., Winters, Maria, DuHadaway, James B., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Rahman, Maisha, Sheikh, Eesha, LaLonde, Judith M., Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724314/
https://ncbi.nlm.nih.gov/pubmed/26717206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.028
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