O-Alkylhydroxylamines as Rationally-designed Mechanism-based Inhibitors of Indoleamine 2,3-Dioxygenase-1

Indoleamine 2,3-dioxygenase-1 (IDO1) is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression. Recently important advances have been made in understanding IDO1’s catalytic mechanism. Although much rem...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Eur J Med Chem
Prif Awduron: Malachowski, William P., Winters, Maria, DuHadaway, James B., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Rahman, Maisha, Sheikh, Eesha, LaLonde, Judith M., Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724314/
https://ncbi.nlm.nih.gov/pubmed/26717206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.028
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