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Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase

Indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan dioxygenase (hTDO) are two of the only three heme-based dioxygenases in humans. They have recently been identified as key cancer immunotherapeutic drug targets. While structures of hIDO1 in complex with inhibitors have been documented, so far ther...

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書目詳細資料
發表在:J Am Chem Soc
Main Authors: Pham, Khoa N., Lewis-Ballester, Ariel, Yeh, Syun-Ru
格式: Artigo
語言:Inglês
出版: 2019
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366343/
https://ncbi.nlm.nih.gov/pubmed/31682426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08871
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