Substrate Stereo-specificity in Tryptophan dioxygenase and Indoleamine 2,3- dioxygenase

The first and rate-limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to N-formylkynurenine is catalyzed by two heme-containing proteins, Indoleamine 2,3-dioxygenase (IDO) and Tryptophan 2,3-dioxygenase (TDO). In mammals, TDO is found exclusively in liver tissue, IDO is...

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Hlavní autoři: Capece, L., Arrar, M., Roitberg, A. E., Yeh, Syun-Ru, Marti, M. A., Estrin, D. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939288/
https://ncbi.nlm.nih.gov/pubmed/20715188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22819
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