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The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies

Tryptophan dioxygenase (TDO) and indole-amine 2,3-dioxygenase (IDO) are two heme-containing enzymes which catalyze the conversion of L-tryptophan to N-formylkynurenine (NFK). In mammals, TDO is mostly expressed in liver and is involved in controlling homeostatic serum tryptophan concentrations, wher...

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Detalles Bibliográficos
Publicado en:J Biol Inorg Chem
Autores principales: Capece, Luciana, Lewis-Ballester, Ariel, Batabyal, Dipanwita, Di Russo, Natali, Yeh, Syun-Ru, Estrin, Dario A., Marti, Marcelo A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533844/
https://ncbi.nlm.nih.gov/pubmed/20361220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-010-0646-x
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