Molecular basis for the substrate stereoselectivity in Tryptophan Dioxygenase

Tryptophan dioxygenase (TDO) and Indoleamine 2,3 dioxygenase (IDO) are the only two heme-proteins that catalyze the oxidation reaction of tryptophan (Trp) to N-formylkynurenine (NFK). While human IDO (hIDO) is able to oxidize both L and D-Trp, human TDO (hTDO) displays a major specificity towards L-...

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Bibliografiske detaljer
Main Authors: Capece, Luciana, Lewis-Ballester, Ariel, Marti, Marcelo A., Estrin, Dario A., Yeh, Syun-Ru
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237892/
https://ncbi.nlm.nih.gov/pubmed/22082147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201439m
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