Cargando...

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an attractive cancer immunotherapeutic target owing to its role in promoting tumoral immune escape. However, drug development has been hindered by limited structural information. Here, we report the crystal structures of hIDO1 in complex with its substr...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Lewis-Ballester, Ariel, Pham, Khoa N., Batabyal, Dipanwita, Karkashon, Shay, Bonanno, Jeffrey B., Poulos, Thomas L., Yeh, Syun-Ru
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700043/
https://ncbi.nlm.nih.gov/pubmed/29167421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01725-8
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!