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Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an attractive cancer immunotherapeutic target owing to its role in promoting tumoral immune escape. However, drug development has been hindered by limited structural information. Here, we report the crystal structures of hIDO1 in complex with its substr...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700043/ https://ncbi.nlm.nih.gov/pubmed/29167421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01725-8 |
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