Feasibility of Flow Cytometry for Measurements of Plasmodium falciparum Parasite Burden in Studies in Areas of Malaria Endemicity by Use of Bidimensional Assessment of YOYO-1 and A...

Por Campo, Joseph J., Aponte, John J., Nhabomba, Augusto J., Sacarlal, Jahit, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Alonso, Pedro L., Dobaño, Carlota
Publicado em 2011

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

Por Linares, María, Viera, Sara, Crespo, Benigno, Franco, Virginia, Gómez-Lorenzo, María G., Jiménez-Díaz, María Belén, Angulo-Barturen, Íñigo, Sanz, Laura María, Gamo, Francisco-Javier
Publicado no Malar J (2015)

Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγ(null) Mice Engrafted with Human Erythrocytes

Por Jiménez-Díaz, María Belén, Mulet, Teresa, Viera, Sara, Gómez, Vanessa, Garuti, Helen, Ibáñez, Javier, Alvarez-Doval, Angela, Shultz, Leonard D., Martínez, Antonio, Gargallo-Viola, Domingo, Angulo-Barturen, Iñigo
Publicado em 2009

A Divergent SAR Study Allows Optimization of a Potent 5-HT(2c) Inhibitor to a Promising Antimalarial Scaffold

Por Calderón, Félix, Vidal-Mas, Jaume, Burrows, Jeremy, de la Rosa, Juan Carlos, Jiménez-Díaz, María Belén, Mulet, Teresa, Prats, Sara, Solana, Jorge, Witty, Michael, Gamo, Francisco Javier, Fernández, Esther
Publicado em 2012

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol

Por Abla, Nada, Bashyam, Sridevi, Charman, Susan A., Greco, Béatrice, Hewitt, Philip, Jiménez-Díaz, Maria Belén, Katneni, Kasiram, Kubas, Holger, Picard, Didier, Sambandan, Yuvaraj, Sanz, Laura, Smith, Dennis, Wang, Tai, Willis, Paul, Wittlin, Sergio, Spangenberg, Thomas
Publicado no ACS Med Chem Lett (2017)

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

Por Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Mulet, Teresa, Rullas, Joaquín, Herreros, Esperanza, Ferrer, Santiago, Jiménez, Elena, Mendoza, Alfonso, Regadera, Javier, Rosenthal, Philip J., Bathurst, Ian, Pompliano, David L., Gómez de las Heras, Federico, Gargallo-Viola, Domingo
Publicado em 2008

Cyclopropyl Carboxamides: A New Oral Antimalarial Series Derived from the Tres Cantos Anti-Malarial Set (TCAMS)

Por Rueda, Lourdes, Castellote, Isabel, Castro-Pichel, Julia, Chaparro, Maria J., de la Rosa, Juan Carlos, Garcia-Perez, Adolfo, Gordo, Mariola, Jimenez-Diaz, Maria Belen, Kessler, Albane, Macdonald, Simon J.F., Martinez, Maria Santos, Sanz, Laura M., Gamo, Francisco Javier, Fernandez, Esther
Publicado em 2011

Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria

Por Skerlj, Renato T., Bastos, Cecilia M., Booker, Michael L., Kramer, Martin L., Barker, Robert H., Celatka, Cassandra A., O’Shea, Thomas J., Munoz, Benito, Sidhu, Amar Bir, Cortese, Joseph F., Wittlin, Sergio, Papastogiannidis, Petros, Angulo-Barturen, Inigo, Jimenez-Diaz, Maria Belen, Sybertz, Edmund
Publicado em 2011

A New In Vivo Screening Paradigm to Accelerate Antimalarial Drug Discovery

Por Jiménez-Díaz, María Belén, Viera, Sara, Ibáñez, Javier, Mulet, Teresa, Magán-Marchal, Noemí, Garuti, Helen, Gómez, Vanessa, Cortés-Gil, Lorena, Martínez, Antonio, Ferrer, Santiago, Fraile, María Teresa, Calderón, Félix, Fernández, Esther, Shultz, Leonard D., Leroy, Didier, Wilson, David M., García-Bustos, José Francisco, Gamo, Francisco Javier, Angulo-Barturen, Iñigo
Publicado em 2013

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

Por McCarthy, James S., Marquart, Louise, Sekuloski, Silvana, Trenholme, Katharine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Iñigo, Ferrer, Santiago, Jiménez-Díaz, María Belén, Martínez, María-Santos, van Huijsduijnen, Rob Hooft, Duparc, Stephan, Leroy, Didier, Wells, Timothy N. C., Baker, Mark, Möhrle, Jörg J.
Publicado no Antimicrob Agents Chemother (2016)

Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

Por Malmquist, Nicholas A., Sundriyal, Sandeep, Caron, Joachim, Chen, Patty, Witkowski, Benoit, Menard, Didier, Suwanarusk, Rossarin, Renia, Laurent, Nosten, Francois, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura M., Gamo, Francisco-Javier, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Fuchter, Matthew J., Scherf, Artur
Publicado no Antimicrob Agents Chemother (2015)

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate p...

Por Coteron, Jose M., Marco, María, Esquivias, Jorge, Deng, Xiaoyi, White, Karen L., White, John, Koltun, Maria, Mazouni, Farah El, Kokkonda, Sreekanth, Katneni, Kasiram, Bhamidipati, Ravi, Shackleford, David M., Barturen, Iñigo Angulo, Ferrer, Santiago B., Jiménez-Díaz, María Belén, Gamo, Francisco-Javier, Goldsmith, Elizabeth J., Charman, William N., Bathurst, Ian, Floyd, David, Matthews, David, Burrows, Jeremy N., Rathod, Pradipsinh K., Charman, Susan A., Phillips, Margaret A.
Publicado em 2011

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Por Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L., Coteron, Jose M., Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R., Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N., Matthews, Dave, Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Publicado no J Med Chem (2016)

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

Por Booker, Michael L., Bastos, Cecilia M., Kramer, Martin L., Barker, Robert H., Skerlj, Renato, Sidhu, Amar Bir, Deng, Xiaoyi, Celatka, Cassandra, Cortese, Joseph F., Guerrero Bravo, Jose E., Crespo Llado, Keila N., Serrano, Adelfa E., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Viera, Sara, Garuti, Helen, Wittlin, Sergio, Papastogiannidis, Petros, Lin, Jing-wen, Janse, Chris J., Khan, Shahid M., Duraisingh, Manoj, Coleman, Bradley, Goldsmith, Elizabeth J., Phillips, Margaret A., Munoz, Benito, Wirth, Dyann F., Klinger, Jeffrey D., Wiegand, Roger, Sybertz, Edmund
Publicado em 2010

Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum

Por Barker, Robert H., Urgaonkar, Sameer, Mazitschek, Ralph, Celatka, Cassandra, Skerlj, Renato, Cortese, Joseph F., Tyndall, Erin, Liu, Hanlan, Cromwell, Mandy, Sidhu, Amar Bir, Guerrero-Bravo, Jose E., Crespo-Llado, Keila N., Serrano, Adelfa E., Lin, Jing-wen, Janse, Chris J., Khan, Shahid M., Duraisingh, Manoj, Coleman, Bradley I., Angulo-Barturen, Inigo, Jiménez-Díaz, María Belén, Magán, Noemí, Gomez, Vanesa, Ferrer, Santiago, Martínez, María Santos, Wittlin, Sergio, Papastogiannidis, Petros, O'Shea, Thomas, Klinger, Jeffrey D., Bree, Mark, Lee, Edward, Levine, Mikaela, Wiegand, Roger C., Munoz, Benito, Wirth, Dyann F., Clardy, Jon, Bathurst, Ian, Sybertz, Edmund
Publicado em 2011

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

Por Phillips, Margaret A., White, Karen L., Kokkonda, Sreekanth, Deng, Xiaoyi, White, John, El Mazouni, Farah, Marsh, Kennan, Tomchick, Diana R., Manjalanagara, Krishne, Rudra, Kakali Rani, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Shackleford, David M., Chiu, Francis C.K., Campbell, Michael, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Martinez, Maria Santos, Lafuente-Monasterio, Maria, Kaminsky, Werner, Silue, Kigbafori, Zeeman, Anne-Marie, Kocken, Clemens, Leroy, Didier, Blasco, Benjamin, Rossignol, Emilie, Rueckle, Thomas, Matthews, Dave, Burrows, Jeremy N., Waterson, David, Palmer, Michael J., Rathod, Pradipsinh K., Charman, Susan A.
Publicado no ACS Infect Dis (2016)

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

Por Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J., Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo–Benito, Francisco Javier, Gnädig, Nina F., Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J., Ng, Caroline L., Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W., Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N., Weller, Thomas, Fischli, Walter, Fidock, David A., Clozel, Martine, Wittlin, Sergio
Publicado no PLoS Med (2016)

Quinolone-3-Diarylethers: A new class of drugs for a new era of malaria eradication

Por Nilsen, Aaron, LaCrue, Alexis N., White, Karen L., Forquer, Isaac P., Cross, Richard M., Marfurt, Jutta, Mather, Michael W., Delves, Michael J., Shackleford, David M., Saenz, Fabian E., Morrisey, Joanne M., Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F., Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E., Kocken, Clemens H. M., Price, Ric N., Avery, Vicky M., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M., Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N., Siegl, Peter, Guy, R. Kiplin, Winter, Rolf W., Vaidya, Akhil B., Charman, Susan A., Kyle, Dennis E., Manetsch, Roman, Riscoe, Michael K.
Publicado no Sci Transl Med (2013)

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Por Hameed P., Shahul, Solapure, Suresh, Patil, Vikas, Henrich, Philipp P., Magistrado, Pamela A., Bharath, Sowmya, Murugan, Kannan, Viswanath, Pavithra, Puttur, Jayashree, Srivastava, Abhishek, Bellale, Eknath, Panduga, Vijender, Shanbag, Gajanan, Awasthy, Disha, Landge, Sudhir, Morayya, Sapna, Koushik, Krishna, Saralaya, Ramanatha, Raichurkar, Anandkumar, Rautela, Nikhil, Roy Choudhury, Nilanjana, Ambady, Anisha, Nandishaiah, Radha, Reddy, Jitendar, Prabhakar, K. R., Menasinakai, Sreenivasaiah, Rudrapatna, Suresh, Chatterji, Monalisa, Jiménez-Díaz, María Belén, Martínez, María Santos, Sanz, Laura María, Coburn-Flynn, Olivia, Fidock, David A., Lukens, Amanda K., Wirth, Dyann F., Bandodkar, Balachandra, Mukherjee, Kakoli, McLaughlin, Robert E., Waterson, David, Rosenbrier-Ribeiro, Lyn, Hickling, Kevin, Balasubramanian, V., Warner, Peter, Hosagrahara, Vinayak, Dudley, Adam, Iyer, Pravin S., Narayanan, Shridhar, Kavanagh, Stefan, Sambandamurthy, Vasan K.
Publicado no Nat Commun (2015)

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Por Jiménez-Díaz, María Belén, Ebert, Daniel, Salinas, Yandira, Pradhan, Anupam, Lehane, Adele M., Myrand-Lapierre, Marie-Eve, O’Loughlin, Kathleen G., Shackleford, David M., Justino de Almeida, Mariana, Carrillo, Angela K., Clark, Julie A., Dennis, Adelaide S. M., Diep, Jonathon, Deng, Xiaoyan, Duffy, Sandra, Endsley, Aaron N., Fedewa, Greg, Guiguemde, W. Armand, Gómez, María G., Holbrook, Gloria, Horst, Jeremy, Kim, Charles C., Liu, Jian, Lee, Marcus C. S., Matheny, Amy, Martínez, María Santos, Miller, Gregory, Rodríguez-Alejandre, Ane, Sanz, Laura, Sigal, Martina, Spillman, Natalie J., Stein, Philip D., Wang, Zheng, Zhu, Fangyi, Waterson, David, Knapp, Spencer, Shelat, Anang, Avery, Vicky M., Fidock, David A., Gamo, Francisco-Javier, Charman, Susan A., Mirsalis, Jon C., Ma, Hongshen, Ferrer, Santiago, Kirk, Kiaran, Angulo-Barturen, Iñigo, Kyle, Dennis E., DeRisi, Joseph L., Floyd, David M., Guy, R. Kiplin
Publicado no Proc Natl Acad Sci U S A (2014)