Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Por Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L., Coteron, Jose M., Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R., Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N., Matthews, Dave, Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Publicado no J Med Chem (2016)

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

Por Phillips, Margaret A., White, Karen L., Kokkonda, Sreekanth, Deng, Xiaoyi, White, John, El Mazouni, Farah, Marsh, Kennan, Tomchick, Diana R., Manjalanagara, Krishne, Rudra, Kakali Rani, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Shackleford, David M., Chiu, Francis C.K., Campbell, Michael, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Martinez, Maria Santos, Lafuente-Monasterio, Maria, Kaminsky, Werner, Silue, Kigbafori, Zeeman, Anne-Marie, Kocken, Clemens, Leroy, Didier, Blasco, Benjamin, Rossignol, Emilie, Rueckle, Thomas, Matthews, Dave, Burrows, Jeremy N., Waterson, David, Palmer, Michael J., Rathod, Pradipsinh K., Charman, Susan A.
Publicado no ACS Infect Dis (2016)