High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

od Giastas, Petros, Neu, Margarete, Rowland, Paul, Stratikos, Efstratios
izdano v ACS Med Chem Lett (2019)

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

od Giastas, Petros, Mpakali, Anastasia, Papakyriakou, Athanasios, Lelis, Aggelos, Kokkala, Paraskevi, Neu, Margarete, Rowland, Paul, Liddle, John, Georgiadis, Dimitris, Stratikos, Efstratios
izdano v Proc Natl Acad Sci U S A (2019)

In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Gro...

od Ross, Leila S., Gamo, Francisco Javier, Lafuente-Monasterio, Maria José, Singh, Onkar M. P., Rowland, Paul, Wiegand, Roger C., Wirth, Dyann F.
Izdano 2014

Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design

od Singh, Onkar, Shillings, Anthony, Craggs, Peter, Wall, Ian, Rowland, Paul, Skarzynski, Tadeusz, Hobbs, Clare I, Hardwick, Phil, Tanner, Rob, Blunt, Michelle, Witty, David R, Smith, Kathrine J
Izdano 2013

Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ

od Spencer, Jonathan A., Baldwin, Ian R., Barton, Nick, Chung, Chun-Wa, Convery, Máire A., Edwards, Christopher D., Jamieson, Craig, Mallett, David N., Rowedder, James E., Rowland, Paul, Thomas, Daniel A., Hardy, Charlotte J.
izdano v ACS Med Chem Lett (2020)

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

od Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker, Ann L., Webster, Scott P., Mowat, Christopher G., Chung, Chun-wa
izdano v Nat Commun (2017)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

od Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N., Palmer, Michael J., Charman, Susan A., Rathod, Pradipsinh K., Phillips, Margaret A.
izdano v ACS Omega (2018)

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

od Mole, Damian J, Webster, Scott P, Uings, Iain, Zheng, Xiaozhong, Binnie, Margaret, Wilson, Kris, Hutchinson, Jonathan P, Mirguet, Olivier, Walker, Ann, Beaufils, Benjamin, Ancellin, Nicolas, Trottet, Lionel, Bénéton, Véronique, Mowat, Christopher G, Wilkinson, Martin, Rowland, Paul, Haslam, Carl, McBride, Andrew, Homer, Natalie ZM, Baily, James E, Sharp, Matthew GF, Garden, O James, Hughes, Jeremy, Howie, Sarah EM, Holmes, Duncan S, Liddle, John, Iredale, John P
izdano v Nat Med (2016)

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

od Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K., Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J., Sheppard, Robert J., Smith, Julia E., Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J., Lee, Kevin, Wilson, David M.
izdano v Nature (2012)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

od Wyllie, Susan, Brand, Stephen, Thomas, Michael, De Rycker, Manu, Chung, Chun-wa, Pena, Imanol, Bingham, Ryan P., Bueren-Calabuig, Juan A., Cantizani, Juan, Cebrian, David, Craggs, Peter D., Ferguson, Liam, Goswami, Panchali, Hobrath, Judith, Howe, Jonathan, Jeacock, Laura, Ko, Eun-Jung, Korczynska, Justyna, MacLean, Lorna, Manthri, Sujatha, Martinez, Maria S., Mata-Cantero, Lydia, Moniz, Sonia, Nühs, Andrea, Osuna-Cabello, Maria, Pinto, Erika, Riley, Jennifer, Robinson, Sharon, Rowland, Paul, Simeons, Frederick R. C., Shishikura, Yoko, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna Gaza, Elisabet, Wall, Richard J., Zuccotto, Fabio, Horn, David, Ferguson, Michael A. J., Fairlamb, Alan H., Fiandor, Jose M., Martin, Julio, Gray, David W., Miles, Timothy J., Gilbert, Ian H., Read, Kevin D., Marco, Maria, Wyatt, Paul G.
izdano v Proc Natl Acad Sci U S A (2019)