Partial Deficiency or Short-Term Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice

Por Sooy, Karen, Webster, Scott P., Noble, June, Binnie, Margaret, Walker, Brian R., Seckl, Jonathan R., Yau, Joyce L. W.
Publicado em 2010

UFSRAT: Ultra-Fast Shape Recognition with Atom Types –The Discovery of Novel Bioactive Small Molecular Scaffolds for FKBP12 and 11βHSD1

Por Shave, Steven, Blackburn, Elizabeth A., Adie, Jillian, Houston, Douglas R., Auer, Manfred, Webster, Scott P., Taylor, Paul, Walkinshaw, Malcolm D.
Publicado no PLoS One (2015)

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

Por Sooy, Karen, Noble, June, McBride, Andrew, Binnie, Margaret, Yau, Joyce L. W., Seckl, Jonathan R., Walker, Brian R., Webster, Scott P.
Publicado no Endocrinology (2015)

Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

Por Yau, Joyce L.W., Wheelan, Nicola, Noble, June, Walker, Brian R., Webster, Scott P., Kenyon, Christopher J., Ludwig, Mike, Seckl, Jonathan R.
Publicado no Neurobiol Aging (2015)

β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction

Por Liu, Xiaoxia, Turban, Sophie, Carter, Roderick N., Ahmad, Shakil, Ramage, Lynne, Webster, Scott P., Walker, Brian R., Seckl, Jonathan R., Morton, Nicholas M.
Publicado em 2014

Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice

Por Wheelan, Nicola, Webster, Scott P., Kenyon, Christopher J., Caughey, Sarah, Walker, Brian R., Holmes, Megan C., Seckl, Jonathan R., Yau, Joyce L.W.
Publicado no Neuropharmacology (2015)

Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure

Por Turban, Sophie, Liu, Xiaoxia, Ramage, Lynne, Webster, Scott P., Walker, Brian R., Dunbar, Donald R., Mullins, John J., Seckl, Jonathan R., Morton, Nicholas M.
Publicado em 2012

Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

Por Cobice, Diego F., Mackay, C. Logan, Goodwin, Richard J. A., McBride, Andrew, Langridge-Smith, Patrick R., Webster, Scott P., Walker, Brian R., Andrew, Ruth
Publicado no Anal Chem (2013)

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

Por Mitić, Tijana, Shave, Steven, Semjonous, Nina, McNae, Iain, Cobice, Diego F., Lavery, Gareth G., Webster, Scott P., Hadoke, Patrick W.F., Walker, Brian R., Andrew, Ruth
Publicado em 2013

Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)

Por Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R
Publicado no Br J Pharmacol (2017)

Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

Por Chapagain, Ananda, Caton, Paul W., Kieswich, Julius, Andrikopoulos, Petros, Nayuni, Nanda, Long, Jamie H., Harwood, Steven M., Webster, Scott P., Raftery, Martin J., Thiemermann, Christoph, Walker, Brian R., Seckl, Jonathan R., Corder, Roger, Yaqoob, Muhammad Magdi
Publicado em 2014

Modulation of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity by 1,5-Substituted 1H-Tetrazoles

Por Webster, Scott P., Binnie, Margaret, McConnell, Kirsty M. M., Sooy, Karen, Ward, Peter, Greaney, Michael F., Vinter, Andy, Pallin, T. David, Dyke, Hazel J., Gill, Matthew I. A., Warner, Ines, Seckl, Jonathan R., Walker, Brian R.
Publicado em 2010

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

Por Coutinho, Agnes E., Kipari, Tiina M. J., Zhang, Zhenguang, Esteves, Cristina L., Lucas, Christopher D., Gilmour, James S., Webster, Scott P., Walker, Brian R., Hughes, Jeremy, Savill, John S., Seckl, Jonathan R., Rossi, Adriano G., Chapman, Karen E.
Publicado no Endocrinology (2016)

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity...

Por Fraser, Craig, Dawson, John C., Dowling, Reece, Houston, Douglas R., Weiss, Jason T., Munro, Alison F., Muir, Morwenna, Harrington, Lea, Webster, Scott P., Frame, Margaret C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado no J Med Chem (2016)

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis

Por Skouras, Christos, Zheng, Xiaozhong, Binnie, Margaret, Homer, Natalie Z. M., Murray, Toby B. J., Robertson, Darren, Briody, Lesley, Paterson, Finny, Spence, Heather, Derr, Lisa, Hayes, Alastair J., Tsoumanis, Andreas, Lyster, Dawn, Parks, Rowan W., Garden, O. James, Iredale, John P., Uings, Iain J., Liddle, John, Wright, Wayne L., Dukes, George, Webster, Scott P., Mole, Damian J.
Publicado no Sci Rep (2016)

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Por Mole, Damian J, Webster, Scott P, Uings, Iain, Zheng, Xiaozhong, Binnie, Margaret, Wilson, Kris, Hutchinson, Jonathan P, Mirguet, Olivier, Walker, Ann, Beaufils, Benjamin, Ancellin, Nicolas, Trottet, Lionel, Bénéton, Véronique, Mowat, Christopher G, Wilkinson, Martin, Rowland, Paul, Haslam, Carl, McBride, Andrew, Homer, Natalie ZM, Baily, James E, Sharp, Matthew GF, Garden, O James, Hughes, Jeremy, Howie, Sarah EM, Holmes, Duncan S, Liddle, John, Iredale, John P
Publicado no Nat Med (2016)