Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

11Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) locally amplifies active glucocorticoids within specific tissues including in brain. In the hippocampus, 11β-HSD1 messenger RNA increases with aging. Here, we report significantly greater increases in intrahippocampal corticosterone (CORT) levels...

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Publicado en:Neurobiol Aging
Autores principales: Yau, Joyce L.W., Wheelan, Nicola, Noble, June, Walker, Brian R., Webster, Scott P., Kenyon, Christopher J., Ludwig, Mike, Seckl, Jonathan R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706164/
https://ncbi.nlm.nih.gov/pubmed/25109766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.07.007
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