Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) intracellularly regenerates active corticosterone from circulating inert 11-dehydrocorticosterone (11-DHC) in specific tissues. The hippocampus is a brain structure particularly vulnerable to glucocorticoid neurotoxicity with aging. In intact hippo...

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Detalhes bibliográficos
Main Authors: Yau, Joyce L. W., Noble, June, Kenyon, Christopher J., Hibberd, Carina, Kotelevtsev, Yuri, Mullins, John J., Seckl, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31900/
https://ncbi.nlm.nih.gov/pubmed/11274359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071562698
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