Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

[Image: see text] Novel pyrazolopyrimidines displaying high potency and selectivity toward SRC family kinases have been developed by combining ligand-based design and phenotypic screening in an iterative manner. Compounds were derived from the promiscuous kinase inhibitor PP1 to search for analogs t...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Med Chem
Autores principales: Fraser, Craig, Dawson, John C., Dowling, Reece, Houston, Douglas R., Weiss, Jason T., Munro, Alison F., Muir, Morwenna, Harrington, Lea, Webster, Scott P., Frame, Margaret C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2016
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885109/
https://ncbi.nlm.nih.gov/pubmed/27115835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00065
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares