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Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening
[Image: see text] Pyrazolopyrimidines with potent antiproliferative properties were developed by an adaptive strategy that applies ligand-based design and phenotypic screening iteratively and is informed by biochemical assays. To drive development toward specific oncopathways, compounds were tested...
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| Veröffentlicht in: | J Med Chem |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2018
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851644/ https://ncbi.nlm.nih.gov/pubmed/29466002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01605 |
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