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Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway

The search for novel targeted inhibitors active on glioblastoma multiforme is crucial to develop new treatments for this unmet clinical need. Herein, we report the results from a screening campaign against glioma cell lines using a proprietary library of 100 structurally-related pyrazolopyrimidines....

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Valero, Teresa, Baillache, Daniel J., Fraser, Craig, Myers, Samuel H., Unciti-Broceta, Asier
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961122/
https://ncbi.nlm.nih.gov/pubmed/31787462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.115215
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