Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR

[Image: see text] The identification and lead optimization of a series of pyridopyrimidinone derivatives are described as a novel class of efficacious dual PI3K/mTOR inhibitors, resulting in the discovery of 31. Compound 31 exhibited high enzyme activity against PI3K and mTOR, potent suppression of...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Yu, Tao, Li, Ning, Wu, Chengde, Guan, Amy, Li, Yi, Peng, Zhengang, He, Miao, Li, Jie, Gong, Zhen, Huang, Lei, Gao, Bo, Hao, Dongling, Sun, Jikui, Pan, Yan, Shen, Liang, Chan, Chichung, Lu, Xiulian, Yuan, Hongyu, Li, Yongguo, Li, Jian, Chen, Shuhui
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846042/
https://ncbi.nlm.nih.gov/pubmed/29541370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00002
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