Discovery of an Orally Bioavailable Dual PI3K/mTOR Inhibitor Based on Sulfonyl-Substituted Morpholinopyrimidines

[Image: see text] The discovery and optimization of a series of 2-morpholino-pyrimidine derivatives containing various sulfonyl side chains at the C(4) position led to the identification of compound 26 as a potent dual PI3K/mTOR inhibitor. It exhibited high inhibitory activity against PI3Kα/β/γ/δ (I...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Shen, Sida, He, Xiangyu, Yang, Zheng, Zhang, Liang, Liu, Yingtao, Zhang, Zhiyuan, Wang, Weiwei, Liu, Wei, Li, Yufeng, Huang, Dong, Sun, Kai, Ni, Xiaojing, Yang, Xu, Chu, Xinxin, Cui, Yumin, Lv, Qiang, Lan, Jiong, Zhou, Fusheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047022/
https://ncbi.nlm.nih.gov/pubmed/30034607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00167
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