Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design

[Image: see text] PI3K, AKT, and mTOR are key kinases from PI3K signaling pathway being extensively pursued to treat a variety of cancers in oncology. To search for a structurally differentiated back-up candidate to PF-04691502, which is currently in phase I/II clinical trials for treating solid tum...

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Detalhes bibliográficos
Main Authors: Cheng, Hengmiao, Li, Chunze, Bailey, Simon, Baxi, Sangita M., Goulet, Lance, Guo, Lisa, Hoffman, Jacqui, Jiang, Ying, Johnson, Theodore Otto, Johnson, Ted W., Knighton, Daniel R., Li, John, Liu, Kevin K.-C., Liu, Zhengyu, Marx, Matthew A., Walls, Marlena, Wells, Peter A., Yin, Min-Jean, Zhu, Jinjiang, Zientek, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027523/
https://ncbi.nlm.nih.gov/pubmed/24900568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300309h
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