Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

This study investigated the antitumour effects of two dual mTOR/PI3K inhibitors, gedatolisib (WYE-129587/PKI-587/PF-05212384) and PF-04691502 against a panel of six human patient derived ovarian cancer xenograft models. Both dual mTOR/PI3K inhibitors demonstrated antitumour activity against all xeno...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Langdon, Simon P., Kay, Charlene, Um, In Hwa, Dodds, Michael, Muir, Morwenna, Sellar, Grant, Kan, Julie, Gourley, Charlie, Harrison, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904563/
https://ncbi.nlm.nih.gov/pubmed/31822716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55096-9
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