ABCB1 and ABCG2 restricts the efficacy of gedatolisib (PF-05212384), a PI3K inhibitor in colorectal cancer cells

BACKGROUND: Overexpression of ABC transporters is a big challenge on cancer therapy which will lead cancer cells resistance to a series of anticancer drugs. Gedatolisib is a dual PI3K and mTOR inhibitor which is under clinical evaluation for multiple types of malignancies, including colorectal cance...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell Int
Asıl Yazarlar: Liu, Changfu, Xing, Wenge, Yu, Haipeng, Zhang, Weihao, Si, Tongguo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2021
Konular:
Primary Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885361/
https://ncbi.nlm.nih.gov/pubmed/33593355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-021-01800-7
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