A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer

BACKGROUND: This phase I, four-arm, open-label study (NCT01347866) evaluated the PI3K/mTOR inhibitors PF-04691502 (arms A, B) and gedatolisib (PF-05212384; arms C, D) in combination with the MEK inhibitor PD-0325901 (arm A, D) or irinotecan (arm B, C) in patients with advanced solid tumors. OBJECTIV...

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Detalhes bibliográficos
Publicado no:Target Oncol
Main Authors: Wainberg, Zev A., Alsina, Maria, Soares, Heloisa P., Braña, Irene, Britten, Carolyn D., Del Conte, Gianluca, Ezeh, Patrick, Houk, Brett, Kern, Kenneth A., Leong, Stephen, Pathan, Nuzhat, Pierce, Kristen J., Siu, Lillian L., Vermette, Jennifer, Tabernero, Josep
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
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Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700209/
https://ncbi.nlm.nih.gov/pubmed/29067643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-017-0530-5
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