Beyond RAS and BRAF: a target rich disease that is ripe for picking

Por Friedrich, Tyler, Leong, Stephen, Lieu, Christopher H.
Publicado no J Gastrointest Oncol (2016)

Seasonal Abundance and Suppression of Fruit-Piercing Moth Eudocima phalonia (L.) in a Citrus Orchard in Sarawak

Por Leong, Stephen Chan Teck, Kueh, Roland Jui Heng
Publicado em 2011

From Bench to Bedside: Lessons Learned in Translating Preclinical Studies in Cancer Drug Development

Por Lieu, Christopher H., Tan, Aik-Choon, Leong, Stephen, Diamond, Jennifer R., Eckhardt, S. Gail
Publicado em 2013

Impacts of Horticultural Mineral Oils and Two Insecticide Practices on Population Fluctuation of Diaphorina citri and Spread of Huanglongbing in a Citrus Orchard in Sarawak

Por Leong, Stephen Chan Teck, Abang, Fatimah, Beattie, Andrew, Kueh, Roland Jui Heng, Wong, Sing King
Publicado em 2012

Elevated Gene Expression in Chalcone Synthase Enzyme Suggests an Increased Production of Flavonoids in Skin and Synchronized Red Cell Cultures of North American Native Grape Berrie...

Por Davis, Gina, Ananga, Anthony, Krastanova, Stoyanka, Sutton, Safira, Ochieng, Joel W., Leong, Stephen, Tsolova, Violetka
Publicado em 2012

The IGF-1R/IR Tyrosine Kinase Inhibitor, PQIP, Exhibits Enhanced Anti-Tumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models

Por Flanigan, Sara A., Pitts, Todd M., Eckhardt, S. Gail, Tentler, John J., Tan, Aik Choon, Thorburn, Andrew, Leong, Stephen
Publicado em 2010

Patient-derived tumour xenografts as models for oncology drug development

Por Tentler, John J., Tan, Aik Choon, Weekes, Colin D., Jimeno, Antonio, Leong, Stephen, Pitts, Todd M., Arcaroli, John J., Messersmith, Wells A., Eckhardt, S. Gail
Publicado em 2012

Multidisciplinary management for esophageal and gastric cancer

Por Boniface, Megan M, Wani, Sachin B, Schefter, Tracey E, Koo, Phillip J, Meguid, Cheryl, Leong, Stephen, Kaplan, Jeffrey B, Wingrove, Lisa J, McCarter, Martin D
Publicado no Cancer Manag Res (2016)

A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors

Por von Mehren, Margaret, Britten, Carolyn D., Pieslor, Peter, Saville, Wayne, Vassos, Artemios, Harris, Sarah, Galluppi, Gerald R., Darif, Mohamed, Wainberg, Zev A., Cohen, Roger B., Leong, Stephen
Publicado em 2014

A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer

Por Zhou, Qing, Gustafson, Daniel, Nallapareddy, Sujatha, Diab, Sami, Leong, Stephen, Lewis, Karl, Gore, Lia, Messersmith, Wells A., Treston, Anthony M., Eckhardt, S. Gail, Sidor, Carolyn, Camidge, D. Ross
Publicado no Invest New Drugs (2010)

Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development

Por Pitts, Todd M., Tan, Aik Choon, Kulikowski, Gillian N., Tentler, John J., Brown, Amy M., Flanigan, Sara A., Leong, Stephen, Coldren, Christopher D., Hirsch, Fred R., Varella-Garcia, Marileila, Korch, Christopher, Eckhardt, S. Gail
Publicado em 2010

Overcoming IGF1R/IR Resistance Through Inhibition of MEK Signaling in Colorectal Cancer Models

Por Flanigan, Sara A., Pitts, Todd M., Newton, Timothy P., Kulikowski, Gillian N., Tan, Aik Choon, McManus, Martine C., Spreafico, Anna, Kachaeva, Maria I., Selby, Heather M., Tentler, John J., Eckhardt, S. Gail, Leong, Stephen
Publicado em 2013

Phase I trial of vandetanib in combination with gemcitabine and capecitabine in patients with advanced solid tumors with an expanded cohort in pancreatic and biliary cancers

Por Kessler, Elizabeth R, Eckhardt, S Gail, Pitts, Todd M, Bradshaw-Pierce, Erica L, O'byrant, Cindy L, Messersmith, Wells A, Nallapreddy, Sujatha, Weekes, Colin, Spratlin, Jennifer, Lieu, Christopher H, Kane, Madeleine A, Eppers, Sarah, Freas, Elizabeth, Leong, Stephen
Publicado no Invest New Drugs (2015)

Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer

Por Tentler, John J., Nallapareddy, Sujatha, Tan, Aik Choon, Spreafico, Anna, Pitts, Todd M., Morelli, M. Pia, Selby, Heather M., Kachaeva, Maria I., Flanigan, Sara A., Kulikowski, Gillian N., Leong, Stephen, Arcarol, John J., Messersmith, Wells A., Eckhardt, S. Gail
Publicado em 2010

Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer

Por Pitts, Todd M., Newton, Timothy P., Bradshaw-Pierce, Erica L., Addison, Rebecca, Arcaroli, John J., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Purkey, Alicia, Tentler, John J., Tan, Aik Choon, Messersmith, Wells A., Eckhardt, S. Gail, Leong, Stephen
Publicado no PLoS One (2014)

Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced...

Por Adjei, Alex A., Cohen, Roger B., Franklin, Wilbur, Morris, Clive, Wilson, David, Molina, Julian R., Hanson, Lorelei J., Gore, Lia, Chow, Laura, Leong, Stephen, Maloney, Lara, Gordon, Gilad, Simmons, Heidi, Marlow, Allison, Litwiler, Kevin, Brown, Suzy, Poch, Gregory, Kane, Katie, Haney, Jerry, Eckhardt, S. Gail
Publicado em 2008

Phase I Pharmacologic and Biologic Study of Ramucirumab (IMC-1121B), a Fully Human Immunoglobulin G(1) Monoclonal Antibody Targeting the Vascular Endothelial Growth Factor Receptor...

Por Spratlin, Jennifer L., Cohen, Roger B., Eadens, Matthew, Gore, Lia, Camidge, D. Ross, Diab, Sami, Leong, Stephen, O'Bryant, Cindy, Chow, Laura Q.M., Serkova, Natalie J., Meropol, Neal J., Lewis, Nancy L., Chiorean, E. Gabriela, Fox, Floyd, Youssoufian, Hagop, Rowinsky, Eric K., Eckhardt, S. Gail
Publicado em 2010

Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies

Por Bowles, Daniel W., Diamond, Jennifer R., Lam, Elaine T., Weekes, Colin D., Astling, David P., Anderson, Ryan T., Leong, Stephen, Gore, Lia, Varella-Garcia, Marileila, Vogler, Brian W., Keysar, Stephen B., Freas, Elizabeth, Aisner, Dara L., Ren, Chen, Tan, Aik-Chook, Wilhelm, Francois, Maniar, Manoj, Eckhardt, S. Gail, Messersmith, Wells A., Jimeno, Antonio
Publicado em 2014