Overcoming IGF1R/IR Resistance Through Inhibition of MEK Signaling in Colorectal Cancer Models

Por Flanigan, Sara A., Pitts, Todd M., Newton, Timothy P., Kulikowski, Gillian N., Tan, Aik Choon, McManus, Martine C., Spreafico, Anna, Kachaeva, Maria I., Selby, Heather M., Tentler, John J., Eckhardt, S. Gail, Leong, Stephen
Publicado em 2013

Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models

Por Diamond, Jennifer R., Eckhardt, S. Gail, Tan, Aik Choon, Newton, Timothy P., Selby, Heather M., Brunkow, Kelsey L., Kachaeva, Maria I., Varella-Garcia, Marileila, Pitts, Todd M., Bray, Mark R., Fletcher, Graham C., Tentler, John J.
Publicado em 2012

Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts

Por Lieu, Christopher H., Klauck, Peter J., Henthorn, Patrick K., Tentler, John J., Tan, Aik-Choon, Spreafico, Anna, Selby, Heather M., Britt, Blair C., Bagby, Stacey M., Arcaroli, John J., Messersmith, Wells A., Pitts, Todd M., Eckhardt, S. Gail
Publicado no Oncotarget (2015)

Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer

Por Tentler, John J., Nallapareddy, Sujatha, Tan, Aik Choon, Spreafico, Anna, Pitts, Todd M., Morelli, M. Pia, Selby, Heather M., Kachaeva, Maria I., Flanigan, Sara A., Kulikowski, Gillian N., Leong, Stephen, Arcarol, John J., Messersmith, Wells A., Eckhardt, S. Gail
Publicado em 2010

Antitumor Activity of the MEK Inhibitor TAK-733 Against Melanoma Cell Lines and Patient-Derived Tumor Explants

Por Micel, Lindsey N., Tentler, John J., Tan, Aik Choon, Selby, Heather M., Brunkow, Kelsey L., Robertson, Kelli M., Davis, S. Lindsey, Klauck, Peter J., Pitts, Todd M., Gangolli, Esha, Fabrey, Robyn, O'Connell, Shawn M., Vincent, Patrick W., Eckhardt, S. Gail
Publicado no Mol Cancer Ther (2014)

Targeting the Protein Ubiquitination Machinery in Melanoma by the NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924)

Por Wong, Kit Man, Micel, Lindsey N., Selby, Heather M., Tan, Aik Choon, Pitts, Todd M., Bagby, Stacey M., Spreafico, Anna, Klauck, Peter J., Blakemore, Stephen J., Smith, Peter F., McDonald, Alice, Berger, Allison, Tentler, John J., Eckhardt, S. Gail
Publicado no Invest New Drugs (2016)

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

Por Davis, S. Lindsey, Robertson, Kelli M., Pitts, Todd M., Tentler, John J., Bradshaw-Pierce, Erica L., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Ecsedy, Jeffrey A., Arcaroli, John J., Messersmith, Wells A., Tan, Aik Choon, Eckhardt, S. Gail
Publicado no Front Pharmacol (2015)

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models

Por Pitts, Todd M., Kulikowski, Gillian N., Tan, Aik-Choon, Murray, Brion W., Arcaroli, John J., Tentler, John J., Spreafico, Anna, Selby, Heather M., Kachaeva, Maria I., McPhillips, Kelly L., Britt, Blair C., Bradshaw-Pierce, Erica L., Messersmith, Wells A., Varella-Garcia, Marileila, Eckhardt, S. Gail
Publicado em 2013

Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer

Por Pitts, Todd M., Bradshaw, Erica L., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Tentler, John J., McPhillips, Kelly, Klauck, Peter J., Capasso, Anna, Diamond, Jennifer R., Davis, S. Lindsey, Tan, Aik Choon, Arcaroli, John J., Purkey, Alicia, Messersmith, Wells A., Ecsedy, Jeffery A., Eckhardt, S. Gail
Publicado no Oncotarget (2016)

Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

Por Spreafico, Anna, Tentler, John J., Pitts, Todd M., Tan, Aik Choon, Gregory, Mark A., Arcaroli, John J., Klauck, Peter J., McManus, Martine C., Hansen, Ryan J., Kim, Jihye, Micel, Lindsey N., Selby, Heather M., Newton, Timothy P., McPhillips, Kelly, Gustafson, Daniel L., DeGregori, James V., Messersmith, Wells A., Winn, Robert A., Eckhardt, S. Gail
Publicado em 2013