Overcoming IGF1R/IR Resistance Through Inhibition of MEK Signaling in Colorectal Cancer Models

由 Flanigan, Sara A., Pitts, Todd M., Newton, Timothy P., Kulikowski, Gillian N., Tan, Aik Choon, McManus, Martine C., Spreafico, Anna, Kachaeva, Maria I., Selby, Heather M., Tentler, John J., Eckhardt, S. Gail, Leong, Stephen
出版 2013

Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models

由 Diamond, Jennifer R., Eckhardt, S. Gail, Tan, Aik Choon, Newton, Timothy P., Selby, Heather M., Brunkow, Kelsey L., Kachaeva, Maria I., Varella-Garcia, Marileila, Pitts, Todd M., Bray, Mark R., Fletcher, Graham C., Tentler, John J.
出版 2012

Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts

由 Lieu, Christopher H., Klauck, Peter J., Henthorn, Patrick K., Tentler, John J., Tan, Aik-Choon, Spreafico, Anna, Selby, Heather M., Britt, Blair C., Bagby, Stacey M., Arcaroli, John J., Messersmith, Wells A., Pitts, Todd M., Eckhardt, S. Gail
發表在 Oncotarget (2015)

Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer

由 Tentler, John J., Nallapareddy, Sujatha, Tan, Aik Choon, Spreafico, Anna, Pitts, Todd M., Morelli, M. Pia, Selby, Heather M., Kachaeva, Maria I., Flanigan, Sara A., Kulikowski, Gillian N., Leong, Stephen, Arcarol, John J., Messersmith, Wells A., Eckhardt, S. Gail
出版 2010

Antitumor Activity of the MEK Inhibitor TAK-733 Against Melanoma Cell Lines and Patient-Derived Tumor Explants

由 Micel, Lindsey N., Tentler, John J., Tan, Aik Choon, Selby, Heather M., Brunkow, Kelsey L., Robertson, Kelli M., Davis, S. Lindsey, Klauck, Peter J., Pitts, Todd M., Gangolli, Esha, Fabrey, Robyn, O'Connell, Shawn M., Vincent, Patrick W., Eckhardt, S. Gail
發表在 Mol Cancer Ther (2014)

Targeting the Protein Ubiquitination Machinery in Melanoma by the NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924)

由 Wong, Kit Man, Micel, Lindsey N., Selby, Heather M., Tan, Aik Choon, Pitts, Todd M., Bagby, Stacey M., Spreafico, Anna, Klauck, Peter J., Blakemore, Stephen J., Smith, Peter F., McDonald, Alice, Berger, Allison, Tentler, John J., Eckhardt, S. Gail
發表在 Invest New Drugs (2016)

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

由 Klauck, Peter J., Bagby, Stacey M., Capasso, Anna, Bradshaw-Pierce, Erica L., Selby, Heather M., Spreafico, Anna, Tentler, John J., Tan, Aik Choon, Kim, Jihye, Arcaroli, John J., Purkey, Alicia, Messersmith, Wells A., Kuida, Keisuke, Gail Eckhardt, S., Pitts, Todd M.
發表在 BMC Cancer (2018)

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

由 Davis, S. Lindsey, Robertson, Kelli M., Pitts, Todd M., Tentler, John J., Bradshaw-Pierce, Erica L., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Ecsedy, Jeffrey A., Arcaroli, John J., Messersmith, Wells A., Tan, Aik Choon, Eckhardt, S. Gail
發表在 Front Pharmacol (2015)

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models

由 Pitts, Todd M., Kulikowski, Gillian N., Tan, Aik-Choon, Murray, Brion W., Arcaroli, John J., Tentler, John J., Spreafico, Anna, Selby, Heather M., Kachaeva, Maria I., McPhillips, Kelly L., Britt, Blair C., Bradshaw-Pierce, Erica L., Messersmith, Wells A., Varella-Garcia, Marileila, Eckhardt, S. Gail
出版 2013

Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer

由 Pitts, Todd M., Bradshaw, Erica L., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Tentler, John J., McPhillips, Kelly, Klauck, Peter J., Capasso, Anna, Diamond, Jennifer R., Davis, S. Lindsey, Tan, Aik Choon, Arcaroli, John J., Purkey, Alicia, Messersmith, Wells A., Ecsedy, Jeffery A., Eckhardt, S. Gail
發表在 Oncotarget (2016)

Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

由 Spreafico, Anna, Tentler, John J., Pitts, Todd M., Tan, Aik Choon, Gregory, Mark A., Arcaroli, John J., Klauck, Peter J., McManus, Martine C., Hansen, Ryan J., Kim, Jihye, Micel, Lindsey N., Selby, Heather M., Newton, Timothy P., McPhillips, Kelly, Gustafson, Daniel L., DeGregori, James V., Messersmith, Wells A., Winn, Robert A., Eckhardt, S. Gail
出版 2013