Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models

The p21-activated kinase (PAK) family of serine/threonine kinases, which are overexpressed in several cancer types, are critical mediators of cell survival, motility, mitosis, transcription, and translation. In the study presented here, we utilized a panel of colorectal cancer (CRC) cell lines to id...

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Hauptverfasser: Pitts, Todd M., Kulikowski, Gillian N., Tan, Aik-Choon, Murray, Brion W., Arcaroli, John J., Tentler, John J., Spreafico, Anna, Selby, Heather M., Kachaeva, Maria I., McPhillips, Kelly L., Britt, Blair C., Bradshaw-Pierce, Erica L., Messersmith, Wells A., Varella-Garcia, Marileila, Eckhardt, S. Gail
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2013
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610060/
https://ncbi.nlm.nih.gov/pubmed/23543898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2013.00035
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