Therapeutic Approaches to RAS Mutation

Por Scott, Aaron J, Lieu, Chris H, Messersmith, Wells A
Publicado no Cancer J (2016)

KRAS Mutation: Comparison of Testing Methods and Tissue Sampling Techniques in Colon Cancer

Por Franklin, Wilbur A., Haney, Jerry, Sugita, Michio, Bemis, Lynne, Jimeno, Antonio, Messersmith, Wells A.
Publicado em 2010

Targeting the WNT Signaling Pathway in Cancer Therapeutics

Por Tai, David, Wells, Keith, Arcaroli, John, Vanderbilt, Chad, Aisner, Dara L., Messersmith, Wells A., Lieu, Christopher H.
Publicado no Oncologist (2015)

Phase I Study of ON 01910.Na, a Novel Modulator of the Polo-Like Kinase 1 Pathway, in Adult Patients With Solid Tumors

Por Jimeno, Antonio, Li, Jing, Messersmith, Wells A., Laheru, Daniel, Rudek, Michelle A., Maniar, Manoj, Hidalgo, Manuel, Baker, Sharyn D., Donehower, Ross C.
Publicado no J Clin Oncol (2008)

Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors

Por Messersmith, Wells A., Jimeno, Antonio, Ettinger, David, Laheru, Dan, Brahmer, Julie, Lansey, Dina, Khan, Yasmin, Donehower, Ross C., Elsayed, Yusri, Zannikos, Peter, Hidalgo, Manuel
Publicado em 2008

Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer

Por Arcaroli, John J., Touban, Basel M., Tan, Aik Choon, Varella-Garcia, Marileila, Powell, Rebecca W., Eckhardt, S. Gail, Elvin, Paul, Gao, Dexiang, Messersmith, Wells A.
Publicado em 2010

Patient-derived tumour xenografts as models for oncology drug development

Por Tentler, John J., Tan, Aik Choon, Weekes, Colin D., Jimeno, Antonio, Leong, Stephen, Pitts, Todd M., Arcaroli, John J., Messersmith, Wells A., Eckhardt, S. Gail
Publicado em 2012

ALDH1B1 as a Modulator of Pancreatic Adenocarcinoma

Por Singh, Surendra, Arcaroli, John J., Orlicky, David J., Chen, Ying, Messersmith, Wells A., Bagby, Stacey, Purkey, Alicia, Quackenbush, Kevin S., Thompson, David C., Vasiliou, Vasilis
Publicado no Pancreas (2016)

Phase I Study of Continuous Weekly Dosing of Dimethylamino Benzoylphenylurea (BPU) in Patients with Solid Tumours

Por Messersmith, Wells A., Rudek, Michelle A., Baker, Sharyn D., Zhao, Ming, Collins, Connie, Colevas, A. Dimitrios, Donehower, Ross C., Carducci, Michael A., Wolff, Antonio C.
Publicado em 2006

[(18)F]Fluorodeoxyglucose Positron Emission Tomography Correlates With Akt Pathway Activity but Is Not Predictive of Clinical Outcome During mTOR Inhibitor Therapy

Por Ma, Wen Wee, Jacene, Heather, Song, Dongweon, Vilardell, Felip, Messersmith, Wells A., Laheru, Dan, Wahl, Richard, Endres, Chris, Jimeno, Antonio, Pomper, Martin G., Hidalgo, Manuel
Publicado em 2009

Stromal Cell-Derived Factor 1α Mediates Resistance to mTOR-Directed Therapy in Pancreatic Cancer

Por Weekes, Colin D, Song, Dongweon, Arcaroli, John, Wilson, Lora A, Rubio-Viqueira, Belen, Cusatis, George, Garrett-Mayer, Elizabeth, Messersmith, Wells A, Winn, Robert A, Hidalgo, Manuel
Publicado em 2012

Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

Por Jimeno, Antonio, Rudek, Michelle A., Purcell, Thomas, Laheru, Daniel A., Messersmith, Wells A., Dancey, Janet, Carducci, Michael A., Baker, Sharyn D., Hidalgo, Manuel, Donehower, Ross C.
Publicado em 2007

An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent

Por Li, Linfeng, Abraham, Adedoyin D., Zhou, Qiong, Ali, Hadi, O’Brien, Jeremy V., Hamill, Brayden D., Arcaroli, John J., Messersmith, Wells A., LaBarbera, Daniel V.
Publicado em 2014

A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer

Por Zhou, Qing, Gustafson, Daniel, Nallapareddy, Sujatha, Diab, Sami, Leong, Stephen, Lewis, Karl, Gore, Lia, Messersmith, Wells A., Treston, Anthony M., Eckhardt, S. Gail, Sidor, Carolyn, Camidge, D. Ross
Publicado no Invest New Drugs (2010)

Phase II trial of concurrent bevacizumab and transhepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma

Por Buijs, Manon, Reyes, Diane K., Pawlik, Timothy M., Blackford, Amanda L., Salem, Riad, Messersmith, Wells A., Weekes, Colin D., Mulcahy, Mary, Kamel, Ihab R., Geschwind, Jean-Francois H.
Publicado em 2012

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Por Bagby, Stacey, Messersmith, Wells A., Pitts, Todd M., Capasso, Anna, Varella-­Garcia, Marileila, Klauck, Peter J., Kim, Jihye, Tan, Aik-Choon, Eckhardt, S. Gail, Tentler, John J., Arcaroli, John
Publicado no J Vis Exp (2016)

Patterns of Care for Locally Advanced Pancreatic Adenocarcinoma Using the National Cancer Database

Por Amini, Arya, Jones, Bernard L., Stumpf, Priscilla, Leong, Stephen, Lieu, Christopher H., Weekes, Colin, Davis, S. Lindsey, Messersmith, Wells A., Purcell, William T., Ghosh, Debashis, Schefter, Tracey, Goodman, Karyn A.
Publicado no Pancreas (2017)

A Phase I Dose‐Escalation Study of Linsitinib (OSI‐906), a Small‐Molecule Dual Insulin‐Like Growth Factor‐1 Receptor/Insulin Receptor Kinase Inhibitor, in Combination with Irinotec...

Por Davis, S. Lindsey, Eckhardt, S. Gail, Diamond, Jennifer R., Messersmith, Wells A., Dasari, Arvind, Weekes, Colin D., Lieu, Christopher H., Kane, Madeline, Choon Tan, Aik, Pitts, Todd M., Leong, Stephen
Publicado no Oncologist (2018)

Thymidylate Synthase (TYMS) Enhancer Region Genotype-Directed Phase II Trial of Oral Capecitabine for 2nd Line Treatment of Advanced Pancreatic Cancer

Por Weekes, Colin D., Nallapareddy, Sujatha, Rudek, Michelle A., Norris-Kirby, Alexis, Laheru, Daniel, Jimeno, Antonio, Donehower, Ross C., Murphy, Kathleen M., Hidalgo, Manuel, Baker, Sharyn D., Messersmith, Wells A.
Publicado em 2010

Phase 1 Study of ABT‐751 in Combination With CAPIRI (Capecitabine and Irinotecan) and Bevacizumab in Patients With Advanced Colorectal Cancer

Por Rudek, Michelle A., Dasari, Arvind, Laheru, Daniel, He, Ping, Jin, Runyan, Walker, Rosalind, Taylor, Gretchen E., Jimeno, Antonio, Donehower, Ross C., Hidalgo, Manuel, Messersmith, Wells A., Purcell, W. Thomas
Publicado no J Clin Pharmacol (2016)