Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Patient derived tumor xenograft (PDTX) models provide a necessary platform in facilitating anti-cancer drug development prior to human trials. Human tumor pieces are injected subcutaneously into athymic nude mice (immunocompromised, T cell deficient) to create a bank of tumors and subsequently are p...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Bagby, Stacey, Messersmith, Wells A., Pitts, Todd M., Capasso, Anna, Varella-­Garcia, Marileila, Klauck, Peter J., Kim, Jihye, Tan, Aik-Choon, Eckhardt, S. Gail, Tentler, John J., Arcaroli, John
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2016
Assuntos:
Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5092181/
https://ncbi.nlm.nih.gov/pubmed/27768028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/54393
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