Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

BACKGROUND: Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends a poor prognosis. TAK-960 is an ATP-competitive Plk1 inhibitor that has demonst...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Klauck, Peter J., Bagby, Stacey M., Capasso, Anna, Bradshaw-Pierce, Erica L., Selby, Heather M., Spreafico, Anna, Tentler, John J., Tan, Aik Choon, Kim, Jihye, Arcaroli, John J., Purkey, Alicia, Messersmith, Wells A., Kuida, Keisuke, Gail Eckhardt, S., Pitts, Todd M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800287/
https://ncbi.nlm.nih.gov/pubmed/29402316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4036-z
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