Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kinase and MEK inhibitor was evaluated in pre-clinical...

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發表在:Front Pharmacol
Main Authors: Davis, S. Lindsey, Robertson, Kelli M., Pitts, Todd M., Tentler, John J., Bradshaw-Pierce, Erica L., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Ecsedy, Jeffrey A., Arcaroli, John J., Messersmith, Wells A., Tan, Aik Choon, Eckhardt, S. Gail
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2015
主題:
Oncology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468631/
https://ncbi.nlm.nih.gov/pubmed/26136684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00120
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