Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kinase and MEK inhibitor was evaluated in pre-clinical...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Davis, S. Lindsey, Robertson, Kelli M., Pitts, Todd M., Tentler, John J., Bradshaw-Pierce, Erica L., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Ecsedy, Jeffrey A., Arcaroli, John J., Messersmith, Wells A., Tan, Aik Choon, Eckhardt, S. Gail
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468631/
https://ncbi.nlm.nih.gov/pubmed/26136684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00120
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