Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kinase and MEK inhibitor was evaluated in pre-clinical...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Davis, S. Lindsey, Robertson, Kelli M., Pitts, Todd M., Tentler, John J., Bradshaw-Pierce, Erica L., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Ecsedy, Jeffrey A., Arcaroli, John J., Messersmith, Wells A., Tan, Aik Choon, Eckhardt, S. Gail
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2015
Gaiak:
Oncology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468631/
https://ncbi.nlm.nih.gov/pubmed/26136684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00120
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