Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer

BACKGROUND: The activation of the MAPK and PI3K/AKT/mTOR pathways is implicated in the majority of cancers. Activating mutations in both of these pathways has been described in colorectal cancer (CRC), thus indicating their potential as therapeutic targets. This study evaluated the combination of a...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Pitts, Todd M., Newton, Timothy P., Bradshaw-Pierce, Erica L., Addison, Rebecca, Arcaroli, John J., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Purkey, Alicia, Tentler, John J., Tan, Aik Choon, Messersmith, Wells A., Eckhardt, S. Gail, Leong, Stephen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234626/
https://ncbi.nlm.nih.gov/pubmed/25401499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113037
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