Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer

BACKGROUND: The activation of the MAPK and PI3K/AKT/mTOR pathways is implicated in the majority of cancers. Activating mutations in both of these pathways has been described in colorectal cancer (CRC), thus indicating their potential as therapeutic targets. This study evaluated the combination of a...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Pitts, Todd M., Newton, Timothy P., Bradshaw-Pierce, Erica L., Addison, Rebecca, Arcaroli, John J., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Purkey, Alicia, Tentler, John J., Tan, Aik Choon, Messersmith, Wells A., Eckhardt, S. Gail, Leong, Stephen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234626/
https://ncbi.nlm.nih.gov/pubmed/25401499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113037
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