Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer

PURPOSE: To evaluate the efficacy of saracatinib (AZD0530), an oral Src inhibitor, in colorectal cancer (CRC) and to identify biomarkers that predict antitumor activity. EXPERIMENTAL DESIGN: Twenty-three CRC cell lines were exposed to saracatinib, and baseline gene expression profiles of three sensi...

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Autori principali: Arcaroli, John J., Touban, Basel M., Tan, Aik Choon, Varella-Garcia, Marileila, Powell, Rebecca W., Eckhardt, S. Gail, Elvin, Paul, Gao, Dexiang, Messersmith, Wells A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805460/
https://ncbi.nlm.nih.gov/pubmed/20682712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0066
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