Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

AZD0530, an orally available Src inhibitor, demonstrated potent antimigratory and anti‐invasive effects in vitro, and inhibited metastasis in a murine model of bladder cancer. Antiproliferative activity of AZD0530 in vitro varied between cell lines (IC50 0.2 –>10μM). AZD0530 inhibited tumor growt...

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發表在:Mol Oncol
Main Authors: Green, Tim P., Fennell, Mike, Whittaker, Robin, Curwen, Jon, Jacobs, Vivien, Allen, Jack, Logie, Armelle, Hargreaves, Judith, Hickinson, D. Mark, Wilkinson, Robert W., Elvin, Paul, Boyer, Brigitte, Carragher, Neil, Plé, Patrick A., Bermingham, Alun, Holdgate, Geoffrey A., Ward, Walter H.J., Hennequin, Laurent F., Davies, Barry R., Costello, Gerard F.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2009
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Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527863/
https://ncbi.nlm.nih.gov/pubmed/19393585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2009.01.002
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