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Phase II Study of the Src Kinase Inhibitor Saracatinib (AZD0530) in Metastatic Melanoma

BACKGROUND: Src kinases are activated in melanoma, and inhibition of Src kinase activity has preclinical anti-tumor effects. Targeting this pathway could therefore have therapeutic activity in patients with metastatic melanoma. PATIENTS AND METHODS: We conducted a multi-center, open-label study of t...

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Main Authors: Gangadhar, Tara C., Clark, Joseph I., Karrison, Theodore, Gajewski, Thomas F.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600382/
https://ncbi.nlm.nih.gov/pubmed/23151808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9897-4
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