Phase I Study of Continuous Weekly Dosing of Dimethylamino Benzoylphenylurea (BPU) in Patients with Solid Tumours

A phase I study of Dimethylamino Benzoylphenylurea (BPU), a tubulin inhibitor, was performed using a weekly continuous schedule. Patients with refractory solid tumours received oral BPU once weekly without interruption at doses ranging from 5 to 320mg using an accelerated titration design. Nineteen...

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Detalhes bibliográficos
Main Authors: Messersmith, Wells A., Rudek, Michelle A., Baker, Sharyn D., Zhao, Ming, Collins, Connie, Colevas, A. Dimitrios, Donehower, Ross C., Carducci, Michael A., Wolff, Antonio C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852493/
https://ncbi.nlm.nih.gov/pubmed/17084620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2006.09.006
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