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Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors
PURPOSE: 7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that inhibits several serine–threonine kinases including PKC and PDK1. Due to the preclinical synergistic effects seen with topoisomerase I inhibitors and non-overlapping toxicity, UCN-01 and irinotecan were combined in a dose-fi...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557498/ https://ncbi.nlm.nih.gov/pubmed/17429623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-007-0485-9 |
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