Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

PURPOSE: 7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that inhibits several serine–threonine kinases including PKC and PDK1. Due to the preclinical synergistic effects seen with topoisomerase I inhibitors and non-overlapping toxicity, UCN-01 and irinotecan were combined in a dose-fi...

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Main Authors: Jimeno, Antonio, Rudek, Michelle A., Purcell, Thomas, Laheru, Daniel A., Messersmith, Wells A., Dancey, Janet, Carducci, Michael A., Baker, Sharyn D., Hidalgo, Manuel, Donehower, Ross C.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557498/
https://ncbi.nlm.nih.gov/pubmed/17429623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-007-0485-9
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