An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent

Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient...

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Main Authors: Li, Linfeng, Abraham, Adedoyin D., Zhou, Qiong, Ali, Hadi, O’Brien, Jeremy V., Hamill, Brayden D., Arcaroli, John J., Messersmith, Wells A., LaBarbera, Daniel V.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178486/
https://ncbi.nlm.nih.gov/pubmed/25244109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12094833
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