Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

Docking studies of tubulin-targeting C2-substituted 7-deazahypoxanthine analogues of marine alkaloid rigidins led to the design and synthesis of compounds containing linear C2-substituents. The C2-alkynyl analogue was found to have double- to single-digit nanomolar antiproliferative IC50 values and...

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Publicado no:J Med Chem
Main Authors: Medellin, Derek C., Zhou, Qiong, Scott, Robert, Matthew Hill, R., Frail, Sarah K., Dasari, Ramesh, Ontiveros, Steven J., Pelly, Stephen C., van Otterlo, Willem A. L., Betancourt, Tania, Shuster, Charles B., Hamel, Ernest, Bai, Ruoli, LaBarbera, Daniel V., Rogelj, Snezna, Frolova, Liliya V., Kornienko, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950951/
https://ncbi.nlm.nih.gov/pubmed/26641132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01426
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