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Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins

C2-aryl- and C2-alkyl-7-deazahypoxanthines as analogues of marine alkaloid rigidins were prepared utilizing novel synthetic methods developed for the construction of the pyrrolo[2,3-d]pyrimidine ring system. The new compounds exhibited submicromolar to nanomolar antiproliferative potencies against a...

詳細記述

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書誌詳細
出版年:ChemMedChem
主要な著者: Scott, Robert, Karki, Menuka, Reisenauer, Mary R., Rodrigues, Roberta, Dasari, Ramesh, Smith, W. Ross, Pelly, Stephen C., van Otterlo, Willem A. L., Shuster, Charles B., Rogelj, Snezna, Magedov, Igor V., Frolova, Liliya V., Kornienko, Alexander
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945961/
https://ncbi.nlm.nih.gov/pubmed/24644272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300532
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