Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins

C2-aryl- and C2-alkyl-7-deazahypoxanthines as analogues of marine alkaloid rigidins were prepared utilizing novel synthetic methods developed for the construction of the pyrrolo[2,3-d]pyrimidine ring system. The new compounds exhibited submicromolar to nanomolar antiproliferative potencies against a...

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Detaylı Bibliyografya
Yayımlandı:ChemMedChem
Asıl Yazarlar: Scott, Robert, Karki, Menuka, Reisenauer, Mary R., Rodrigues, Roberta, Dasari, Ramesh, Smith, W. Ross, Pelly, Stephen C., van Otterlo, Willem A. L., Shuster, Charles B., Rogelj, Snezna, Magedov, Igor V., Frolova, Liliya V., Kornienko, Alexander
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945961/
https://ncbi.nlm.nih.gov/pubmed/24644272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300532
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