An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent

Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient...

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Bibliographic Details
Main Authors: Li, Linfeng, Abraham, Adedoyin D., Zhou, Qiong, Ali, Hadi, O’Brien, Jeremy V., Hamill, Brayden D., Arcaroli, John J., Messersmith, Wells A., LaBarbera, Daniel V.
Format: Artigo
Language:Inglês
Published: MDPI 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178486/
https://ncbi.nlm.nih.gov/pubmed/25244109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12094833
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