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An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent

Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient...

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מידע ביבליוגרפי
Main Authors: Li, Linfeng, Abraham, Adedoyin D., Zhou, Qiong, Ali, Hadi, O’Brien, Jeremy V., Hamill, Brayden D., Arcaroli, John J., Messersmith, Wells A., LaBarbera, Daniel V.
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178486/
https://ncbi.nlm.nih.gov/pubmed/25244109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12094833
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