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Analogs of the marine alkaloid makaluvamines: Synthesis, topoisomerase II inhibition and anticancer activity
Twelve analogs of makaluvamines have been synthesized. These compounds were evaluated for their ability to inhibit the enzyme topoisomerase II. Five compounds were shown to inhibit topoisomerase catalytic activity comparable to two known topoisomerase II targeting control drugs, etoposide and m-AMSA...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706148/ https://ncbi.nlm.nih.gov/pubmed/17368022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.02.065 |
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