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Analogs of the marine alkaloid makaluvamines: Synthesis, topoisomerase II inhibition and anticancer activity
Twelve analogs of makaluvamines have been synthesized. These compounds were evaluated for their ability to inhibit the enzyme topoisomerase II. Five compounds were shown to inhibit topoisomerase catalytic activity comparable to two known topoisomerase II targeting control drugs, etoposide and m-AMSA...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706148/ https://ncbi.nlm.nih.gov/pubmed/17368022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.02.065 |
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