Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer

P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overexpressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309), a novel...

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Detalhes bibliográficos
Main Authors: Bradshaw-Pierce, Erica Lynn, Pitts, Todd M., Tan, Aik-Choon, McPhillips, Kelly, West, Mark, Gustafson, Daniel L., Halsey, Charles, Nguyen, Leslie, Lee, Nathan V., Kan, Julie L. C., Murray, Brion William, Eckhardt, S. Gail
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605511/
https://ncbi.nlm.nih.gov/pubmed/23524533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2013.00022
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