Antitumor Activity of the MEK Inhibitor TAK-733 Against Melanoma Cell Lines and Patient-Derived Tumor Explants

The goal of this study was to investigate the activity of the selective MEK 1/2 inhibitor, TAK-733, in both melanoma cell lines and patient-derived melanoma xenograft models. In vitro cell proliferation assays using the SRB assay were conducted to determine TAK-733 potency and melanoma responsivenes...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cancer Ther
Egile Nagusiak: Micel, Lindsey N., Tentler, John J., Tan, Aik Choon, Selby, Heather M., Brunkow, Kelsey L., Robertson, Kelli M., Davis, S. Lindsey, Klauck, Peter J., Pitts, Todd M., Gangolli, Esha, Fabrey, Robyn, O'Connell, Shawn M., Vincent, Patrick W., Eckhardt, S. Gail
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671492/
https://ncbi.nlm.nih.gov/pubmed/25376610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1012
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