Antitumor Activity of the MEK Inhibitor TAK-733 Against Melanoma Cell Lines and Patient-Derived Tumor Explants

The goal of this study was to investigate the activity of the selective MEK 1/2 inhibitor, TAK-733, in both melanoma cell lines and patient-derived melanoma xenograft models. In vitro cell proliferation assays using the SRB assay were conducted to determine TAK-733 potency and melanoma responsivenes...

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Gepubliceerd in:Mol Cancer Ther
Hoofdauteurs: Micel, Lindsey N., Tentler, John J., Tan, Aik Choon, Selby, Heather M., Brunkow, Kelsey L., Robertson, Kelli M., Davis, S. Lindsey, Klauck, Peter J., Pitts, Todd M., Gangolli, Esha, Fabrey, Robyn, O'Connell, Shawn M., Vincent, Patrick W., Eckhardt, S. Gail
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671492/
https://ncbi.nlm.nih.gov/pubmed/25376610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1012
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